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Partners' Projects
Jade Lai

Jade Lai

C57BL/6J & 6N

I want to order some gene edited mice model. But I am curious about the different between C57BL/6J and 6N, are they the same or different? Actually, B6N are 99% identical to B6J, and they can be used for most…

Congenital Thrombotic Thrombocytopenic(cTTP)

What Is Congenital Thrombotic Thrombocytopenic Purpura? Congenital Thrombotic Thrombocytopenic Purpura (cTTP), also named congenital ADAMTS13 deficiency, is an extremely rare inherited hematologic disease. As one of the two major subtypes of thrombotic thrombocytopenic purpura (TTP), it differs from immune-mediated acquired…

Isovaleric Acidemia

What Is Isovaleric Acidemia? Isovaleric Acidemia (IVA) is a rare autosomal recessive inborn organic acid metabolic disorder caused by pathogenic variants in the IVD gene encoding isovaleryl-CoA dehydrogenase. Gene defects block leucine catabolism, leading to massive systemic accumulation of toxic…

Gangliosidosis:GM1/GM2-Tay-Sachs/Sandhoff

What Is Gangliosidosis? Gangliosidosis encompasses a group of autosomal recessive lysosomal storage diseases caused by defects in lysosomal hydrolases or accessory proteins, leading to pathological accumulation of gangliosides within the central nervous system (CNS). Based on the defective protein, the…

Severe Congenital Neutropenia

What Is Severe Congenital Neutropenia? Severe Congenital Neutropenia (SCN) is a rare inherited bone marrow failure syndrome characterized by arrested myeloid differentiation, with an estimated prevalence of 3–8.5 cases per million people. Due to profound neutropenia, patients suffer recurrent infections…

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