The Next Generation of Mouse Model Preparation Platform
- 4-Week Delivery: World’s fastest custom mouse model development.
- TurboMice™ Tech: Proprietary high-efficiency gene-editing platform.
- Full Capabilities: Expert conditional knockouts, knock-ins, and humanized models.
- Validated Quality: Guaranteed high precision and model viability.
VeloGene Biotechnology
Transgenic Mouse
for Research
From Cell to Mice by TurboMice™
- AAALAC
- ISO
- F0 Direct Usability: Ready for experiments instantly.
- 3–5 Month Delivery: 2× faster than the traditional 6–12 month timeline.
- Complex Structure Constructions: Support fragment >20kb and Multi-component Editing
- Minimum Genetic Drift: Clone-level uniformity with absolute background consistency.
- IP Ownership: Strict fee-for-service model with absolute protection and no third-party resale.
- 2-Year Free ESC Banking: Effortless batch re-ordering in just 2 months.
- SPF Level Delivery From Door to Door
Get Your Project Evaluated by Our Scientist for Free
Or contact us here!
* Get a free, no-obligation feasibility assessment for your mouse project.
* All project information shared is strictly confidential, and your IP rights are fully protected.
Our team will respond within 24 working hours. We will not make unsolicited phone calls.
How Long it Takes to Get My Lab-Ready F0 Transgenic Mice?
The next generation of mouse model preparation platform. By using tetraploid complementation technology, TurboMice™ allows us to shorten the time to 3-5 months. 2× faster than the traditional 6–12 month workflow.
4 - 6 Weeks→
Designing & Targeting Vector Constructing
4 - 6 Weeks→
Cell Editing & Screening
3 - 4 Weeks→
Tetraploid Mouse Producing
3 Weeks→
Weaned & Ready to Transport
Total:
3-5 Months
SPF level stable delivery from door to door
Re-ordering Mice in the Same Gene in 45 Days
by TurboMice™ ES Banking Technology
Leveraging advanced sperm cryopreservation, purification, and rederivation, we help you bypass traditional breeding bottlenecks. Whether dealing with limited male mice, pathogen contamination risks, or mating failures, our technology allows you to repeatedly obtain genetically identical, pathogen-free mouse cohorts with uniform ages in just about 45 days—saving time, cost, and animal housing space while securing your valuable genetic resources.
How to Get my
Transgenic
Mouse Model?
We will determine the best approach for your desired transgenic mouse model base on your requirements.
Send Your Inquiry
Before we start, you can start by submitting your inquiry form or talk to us on our Whatsapp and tell us what you need!
Solution Design
We will reply to you as soon as possible and send you a quote!
TurboMicing
We will get hands on your project.
Get your Ready to Use f0 Mice!
Our f0 homozygous mice will ship to you and lab-ready!
Full Qualification
VeloGene Biotechnology Shares the Qualifications of Its Parent Company - MingCeler Biotech
Including AAALAC, ISO, and China Laboratory Animal Production License
Clients Across the Continents
Our Clients Are Located Throughout the Asia Pacific, North America, and Europe with Seamless Global Delivery
Backed by our robust global delivery capabilities extending to clients in South Korea, the US, Germany, Sweden, and beyond, our reliable logistics and seamless customs compliance serve as your strongest guarantee, ensuring a stable, secure door-to-door journey from our facility straight to your lab using custom-built transport cages that fully comply with animal welfare standards, strict SPF-grade requirements, and multi-country import-export quarantine regulations for smooth customs clearance worldwide.
Client Cases
Scroll Down to See Technical Details on VeloGene Biotechnology's
Transgenic Mouse Model Technical Details
Comparison, Advantages and FAQ
VeloGene Biotechnology Transgenic Mouse Model Customizing Service
Beyond Random Integration: TurboMice™ Clone-Level Uniform Models Delivered in 3–5 Months
Tradition Transgenic vs TurboMice™ Transgenic
| Metrics | Traditional Pronuclear Injection Transgenic Mice | VeloGene TurboMice™ Transgenic Customization |
|---|---|---|
| Gene Integration Method | Random integration, multi-copy anomalies common | ESC site-specific integration, monoclonal origin |
| Time to Obtain Usable Experimental Mice | 6–12 months (requires founder screening + multi-generation breeding) | Delivery in 3–5 months |
| Expression Consistency | Large individual variations, prone to expression silencing | F0 is homozygous, uniform and stable expression |
| Complex Structure Construction | Extremely difficult to achieve large fragments or complex arrangements | Supports >20 kb long fragments and multi-component editing |
| Cryopreservation & Expansion | Relies on sperm/embryo, recovery and breeding takes 1 year+ | ESC cryopreservation, batch delivery within 2 months |
VeloGene Biotechnology's Transgenic Mouse Solutions Advantages
- Site-specific Knock-in (KI): Precisely insert reporter genes (e.g., EGFP, mCherry) and Cre recombinase into specific loci (e.g., Rosa26) to achieve stable and uniform expression.
- Large-Fragment Functional Element Overexpression: Over 20 kb long fragments (e.g., pathogenic genes containing complete regulatory elements, human BAC equivalent replacements), solving the problem of expression instability caused by random integration.
- Multi-Gene Array / Complex Structures: Construct complex transgenic vectors containing multiple promoters, regulatory elements, or dual/triple genes, used to simulate multi-gene regulatory networks or build complex disease models.
- Conditional Transgenic Models: Combined with the Cre-LoxP system, achieving spatiotemporally specific gene expression regulation.
VeloGene's Delivery Period(As quick as in 3 months)
- Strategy Customization & Vector Construction: 1–4 weeks
- ESC Editing & Monoclonal Screening and Validation: 3–6 weeks
- Tetraploid Compensation Mouse Generation: 4–6 weeks
- Weaning, QC, and Shipping: ~3 weeks
Why Choose VeloGene Biotechnology and TurboMice™ for Custom Transgenic Mouse Models?
VeloGene Biotechnology is the pioneer team in the industrialization of TurboMice™ tetraploid complementation technology, raising the live birth rate of tetraploid embryos from the 1–5% reported in literature to 30%–60%, truly replacing ‘mouse breeds mice’ with ‘cell to mice.’ The platform has successfully delivered a large number of complex transgenic models, including large-fragment functional gene overexpression, multi-target humanization, and complex conditional models, providing highly reproducible animal models for drug screening and mechanistic studies.
How to get your mice?
Send Your Inquiry
Before we start, you can start by submitting your inquiry form or talk to us on our Whatsapp and tell us what you need!
Solution Design
We will reply to you as soon as possible and send you a quote!
TurboMicing
We will get hands on your project.
Get your Ready to Use f0 Mice!
Our f0 homozygous mice will ship to you and lab-ready!
Frequent Asks
Traditional transgenic mouse founders show large individual variations. How do you ensure consistency?
Traditional methods rely on pronuclear injection, where exogenous genes randomly integrate into the genome, leading to varying copy numbers and integration sites that trigger expression differences. TurboMice™ achieves site-specific integration at the ESC stage, and all F0 mice originate from the same verified ESC monoclonal line, resulting in high genotype and phenotype consistency and completely resolving the issue of genetic drift.
My gene fragment exceeds 20 kb. Can this be done?
Absolutely. ESC homologous recombination is not subject to the capacity limitations of pronuclear injection. MingCeler has successfully delivered multiple long-fragment transgenic projects exceeding 20 kb as well as multi-locus combination projects, ensuring stable integration and expression of large fragments.
Can F0 generation transgenic mice be used directly for efficacy or phenotypic experiments?
Positive. The F0 generation of TurboMice™ consists of homozygotes whose somatic cells uniformly carry the transgene, and their genotypes and other factors undergo strict QC validation, allowing them to proceed directly to efficacy evaluations or basic phenotypic studies in fields such as oncology, immunology, and metabolism.
What if I want more mice in the future?
We cryopreserve the original ESC clones used to build your model. When additional mice are needed, direct thawing and tetraploid compensation production can be performed, enabling batch delivery of live mice in just 2 months with an identical genetic background to the initial batch.
IP Assurance
At VeloGene, we operate on a strict fee-for-service model. All intellectual property (IP) and materials created for your project are 100% yours. We take every measure to safeguard your IP, ensuring no vectors, ES cells, or mouse lines are retained or resold to third parties. This way, you can focus on your research with complete peace of mind.