The Next Generation of Mouse Model Preparation Platform
- 4-Week Delivery: World’s fastest custom mouse model development.
- TurboMice™ Tech: Proprietary high-efficiency gene-editing platform.
- Full Capabilities: Expert conditional knockouts, knock-ins, and humanized models.
- Validated Quality: Guaranteed high precision and model viability.
VeloGene Biotechnology
Genetically Humanized Mouse for Research
From Cell to Mice by TurboMice™
- AAALAC
- ISO
- F0 Direct Usability: Ready for experiments instantly.
- 3–5 Month Delivery: 2× faster than the traditional 6–12 month timeline.
- Multi-Site Customization on Same Chromosome: Simultaneous integration multiple locus on the same chromosome.
- Minimum Genetic Drift: Clone-level uniformity with absolute background consistency.
- IP Ownership: Strict fee-for-service model with absolute protection and no third-party resale.
- 2-Year Free ESC Banking: Effortless batch re-ordering in just 2 months.
- SPF Level Delivery From Door to Door
Get Your Project Evaluated by Our Scientist for Free
Or contact us here!
* Get a free, no-obligation feasibility assessment for your mouse project.
* All project information shared is strictly confidential, and your IP rights are fully protected.
Our team will respond within 24 working hours. We will not make unsolicited phone calls.
How Long it Takes to Get My Lab-Ready F0 Genetically Humanized Mice?
The next generation of mouse model preparation platform. By using tetraploid complementation technology, TurboMice™ allows us to shorten the time to 3-5 months. 2× faster than the traditional 6–12 month workflow.
4 - 6 Weeks→
Designing & Targeting Vector Constructing
4 - 6 Weeks→
Cell Editing & Screening
3 - 4 Weeks→
Tetraploid Mouse Producing
3 Weeks→
Weaned & Ready to Transport
Total:
3-5 Months
SPF level stable delivery from door to door
Re-ordering Mice in the Same Gene in 45 Days
by TurboMice™ ES Banking Technology
Leveraging advanced sperm cryopreservation, purification, and rederivation, we help you bypass traditional breeding bottlenecks. Whether dealing with limited male mice, pathogen contamination risks, or mating failures, our technology allows you to repeatedly obtain genetically identical, pathogen-free mouse cohorts with uniform ages in just about 45 days—saving time, cost, and animal housing space while securing your valuable genetic resources.
How to Get my
Genetically Humanized
Mouse Model?
We will determine the best approach for your desired humanized mouse model base on your requirements.
Send Your Inquiry
Before we start, you can start by submitting your inquiry form or talk to us on our Whatsapp and tell us what you need!
Solution Design
We will reply to you as soon as possible and send you a quote!
TurboMicing
We will get hands on your project.
Get your Ready to Use f0 Mice!
Our f0 homozygous mice will ship to you and lab-ready!
Full Qualification
VeloGene Biotechnology Shares the Qualifications of Its Parent Company - MingCeler Biotech
Including AAALAC, ISO, and China Laboratory Animal Production License
Clients Across the Continents
Our Clients Are Located Throughout the Asia Pacific, North America, and Europe with Seamless Global Delivery
Backed by our robust global delivery capabilities extending to clients in South Korea, the US, Germany, Sweden, and beyond, our reliable logistics and seamless customs compliance serve as your strongest guarantee, ensuring a stable, secure door-to-door journey from our facility straight to your lab using custom-built transport cages that fully comply with animal welfare standards, strict SPF-grade requirements, and multi-country import-export quarantine regulations for smooth customs clearance worldwide.
Client Cases
Scroll Down to See Technical Details on VeloGene Biotechnology's
Humanized Mouse Model Technical Details
Comparison, Advantages and FAQ
VeloGene Biotechnology Genetically Humanized Mouse Model Customization Service
F0 "Founder" Ready - to -Use
Humanized mice refer to genetically engineered mouse models in which human functional genes, coding regions, or regulatory elements are in situ replaced with their mouse orthologous sequences, enabling the mice to express human proteins in vivo and simulate human pathological responses.
VeloGene Biotechnology TurboMice™：
- Core Technology: TurboMice™ tetraploid complementation technology performs in situ humanized editing at the embryonic stem cell (ESC) level.
- Developmental Mechanism: Edited ESCs are aggregated with tetraploid embryos—which exclusively develop into extraembryonic tissues like the placenta—to provide developmental compensation.
- F0 Generation: All resulting F0 generation mice originate from the exact same edited ESC single clone.
- Efficiency & Timeline: Delivers homozygous, stably inheritable humanized mice within a timeframe of 3 to 5 months.
Tradition Humanized vs TurboMice™ Humanized
| Comparison Metrics | Traditional Method (ES Chimerism / Pronuclear Injection / BAC) | VeloGene TurboMice™ Humanized Customization |
|---|---|---|
| Time to Obtain Homozygous Usable Humanized Mice | 6–12 months (multi-generation intercrossing & screening) | 3–5 months for delivery |
| Long-Fragment Humanization (>20 kb) | Extremely difficult; BAC random insertion leads to unstable expression | In situ precise gene editing |
| Multi-locus Editing on the Same Chromosome (Multi-point Humanization) | Linkage drift and out-of-control intercrossing | ESC homologous recombination |
| Direct Usability of F0 for Experiments | Mostly chimeric / heterozygous | Yes, F0 mice are directly homozygous with full genotypes |
| Genetic Background Consistency | Prone to genetic drift through multi-generation intercrossing | Identical clone-level uniformity via same-strain ESCs |
| Cryopreservation & Recovery | Sperm/embryo cryopreservation, recovery & breeding takes 1 year+ | ESC cryopreservation, batch delivery within 2 months post-recovery |
VeloGene Biotechnology's Humanized Mouse Solutions Advantages
VeloGene Biotech's TurboMice™ Humanize Service Can Cover Complex Scenarios
- Single-gene humanization (CDS / single-exon / multi-exon / full-coding-region replacement)
- Protein domain humanization, point mutation combinatorial humanization
- Dual/triple-gene humanization arrays (immune checkpoints, cytokine clusters)
- Long-fragment humanization over 20 kb (such as HLA clusters, immunoglobulin loci, PCSK9 regions)
VeloGene's Delivery Period(As quick as in 3 months)
- Editing strategy customization: 1–2 days
- Vector construction: 2–4 weeks
- ESC editing + single-clone verification: 3–6 weeks
- Tetraploid complementation mouse Weaning, quality inspection & shipping: Approx. 3 weeks
Homozygous Humanized Mice Delivered in as Fast as 3-5 Months (Rapid batch generation from ES cells to mice takes approximately 45 days at the fastest)
Order Now to Receive 2 Years of Free ESC Cryopreservation/Banking (No need for re-mating for subsequent cohort expansion; batch delivery in approximately 2 months)
Clients Cases
1. GeneAssist and VeloGene Biotechnology Jointly Announce: Launch of the World's First/Series of Humanized DMD Mouse Models to Empower Global New Drug R&D
DMD is a fatal X-linked recessive genetic disease and one of the most challenging problems in the field of rare diseases. The long-standing lack of animal models that can accurately simulate the pathological characteristics of human patients has been a key bottleneck restricting the clinical translation rate of global DMD drug development.
To address these pain points, GeneAssist, leveraging its deep expertise in gene editing technology and the DMD disease field, has partnered with VeloGene Biotechnology’s globally leading TurboMice™ tetraploid complementation technology platform. Together, they have successfully broken through the technical barriers of complex DMD model construction, developing multiple humanized DMD animal models that highly recapitulate human disease phenotypes. The humanized DMD exon 50, 51, 53, and 45 mouse models cover over 30% of the DMD patient population, making them particularly suitable for the preclinical evaluation of DMD exon-skipping therapies.
2. VeloGene Biotechnology Congratulates Partner AccurEdit Therapeutics on Receiving US FDA IND Clearance for In Vivo Gene Editing Therapy ART001
VeloGene Biotechnology leveraged its high-efficiency TurboMice™ tetraploid complementation technology to rapidly complete the iteration of 2nd-generation new target animal models for AccurEdit Therapeutics in just 4 months. This successfully developed humanized gene editing mouse models carrying rare human genetic disease mutations with ideal phenotypes, which were quickly mass-produced for the preclinical study of ART001, contributing to the acceleration of innovative gene therapy R&D for ATTR diseases.
Related Products
How to get your mice?
Send Your Inquiry
Before we start, you can start by submitting your inquiry form or talk to us on our Whatsapp and tell us what you need!
Solution Design
We will reply to you as soon as possible and send you a quote!
TurboMicing
We will get hands on your project.
Get your Ready to Use f0 Mice!
Our f0 homozygous mice will ship to you and lab-ready!
Frequent Asks
Humanized mice from scratch traditionally take more than 6 months. Can you really deliver in 3 months?
Traditional method involves vector construction + ES chimerism + germline transmission + homozygous screening; whereas TurboMice™ completes the humanization all at once at the ESC level, with founder mice (F0) being directly homozygous, enabling the delivery of experiment-ready mice within 3 to 5 months.”
Is >20kb long fragment humanizing really possible?
Affirmative. ESC homologous recombination is not limited by pronuclear injection volume, and VeloGene has successfully delivered orders involving humanization and multi-locus combinations of over 20 kb.
Can F0 generation humanized mice be used directly for pharmacodynamic experiments?
Positive. F0 whole-body cells uniformly carry the humanized allele, and protein expression is verified via QC. They can directly enter tumor, immunity, and infection evaluations without the need for further expansion.
What if I want more mice in the future?
Cryopreserved ESC clones are directly revived to edit lines, delivering live animals in batches within 2 months, featuring identical strain and origin with zero genetic drift.
IP Assurance
At VeloGene, we operate on a strict fee-for-service model. All intellectual property (IP) and materials created for your project are 100% yours. We take every measure to safeguard your IP, ensuring no vectors, ES cells, or mouse lines are retained or resold to third parties. This way, you can focus on your research with complete peace of mind.