hIL9R Mouse Model
| Strain Name | hIL9R Mouse Model |
|---|---|
| Strain Background | C57BL/6N |
Applications
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Asthma & allergy research: Study IL-9–driven mucus secretion, mast cell activation, and airway hyperreactivity.
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Autoimmune disease modeling: Ulcerative colitis and MS-related demyelination involving IL-9R pathology.
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Anti–IL-9R drug testing: Evaluate human monoclonal antibodies for efficacy and pharmacodynamics.
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JAK-STAT signaling studies: Dissect IL-9–induced STAT activation and downstream gene programs.
Strain Description
The hIL9R Mouse Model carries a targeted knock-in of the human IL9RA gene at the endogenous mouse locus. It replaces the murine Il9ra coding sequence while preserving native promoters and regulatory elements. This ensures physiological expression of functional human IL-9RA (IL-9 receptor α chain) in the same cell types where the endogenous gene is normally expressed, including T cells, mast cells, eosinophils, and epithelial cells.
In this hIL9R model, IL-9R signaling through JAK1/JAK3 activates STAT1, STAT3, and STAT5 to regulate genes involved in survival, proliferation, and cytokine production. In allergic asthma and ulcerative colitis, IL-9R drives mucus hypersecretion, mast cell activation, and barrier dysfunction. Dysregulated IL-9R signaling also contributes to autoimmune demyelination and certain hematologic malignancies.
This humanized IL9R model allows therapeutic antibodies such as anti–IL-9R monoclonal antibodies to bind human IL-9RA in vivo. It thus provides a translational platform for evaluating IL-9/IL-9R–targeted drugs, studying Th9 cell biology, and modeling human IL-9R–associated inflammatory diseases that conventional models cannot replicate.
FAQ
Game-changing benefits？
While competitors highlight germline efficiency gains, shorter timelines and enhanced 3Rs animal welfare benefits for their technologies, these are merely incremental improvements over traditional approaches. In sharp contrast, our proprietary technology delivers fully pure, homogeneous lineages—every single cell of the mice is derived exclusively from totipotent ES cells, with guaranteed 100% germline transmission efficiency. To experience these unparalleled benefits firsthand, enquire about your custom mouse model project with us or order embryos for in-house validation at your facility.
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•Free initial design proposal with zero obligations.
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Who owns the mouse lP? Do l need a licence from Mingceler?
All model generation projects of Mingceler operate under a fee-for-service framework.
IP Ownership: All intellectual property rights related to custom mouse models, including derived organs, tissues, cells, and biological materials, are the sole and exclusive property of the Client.
Third-Party Transfer Permission: The Client may independently decide to retain, utilize, or commercialize their custom models project materials (e.g., targeting vectors, ES cells, mouse lines) without the need for prior consent from Mingceler.
Licensing Exemption: The Client has full autonomy over all uses of the custom models or their derivatives, including but not limited to commercialization, distribution to third parties, and publication involving model data. No written license from Mingceler is required for such uses.