hHGF/hMET Mouse Model
| Strain Name | hHGF/hMET Mouse Model |
|---|---|
| Strain Background | C57BL/6N |
Applications
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MET inhibitor testing: Evaluate MET TKIs and anti-HGF mAbs in vivo.
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HGF-dependent xenografts: Support PDX/CDX lines needing human HGF for growth.
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Signaling studies: Dissect HGF–MET–PI3K/ERK/STAT3 axis in tumor progression.
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Combination therapy: Model stromal HGF impact on targeted or immune checkpoint response.
Strain Description
The hHGF/hMET Mouse Model carries targeted knock-in of the human HGF and/or MET genes at their endogenous mouse loci. It replaces the murine HGF or MET coding sequences while preserving native promoters and regulatory elements. Therefore, it ensures physiological expression of functional human HGF and/or c-MET receptor in the same tissues and cell types where the endogenous genes are normally expressed.
This humanized HGF MET model allows therapeutics to engage authentic human targets. For example, you can test selective MET kinase inhibitors (e.g., capmatinib analogs) or anti-HGF neutralizing antibodies. Similarly, it supports HGF-dependent patient-derived xenografts (PDX) that fail to grow in wild-type hosts. Consequently, the hHGF/hMET Mouse Model provides a translational platform for MET-targeted drug efficacy, combination studies, and mechanism validation that conventional models cannot replicate.
FAQ
Game-changing benefits？
While competitors highlight germline efficiency gains, shorter timelines and enhanced 3Rs animal welfare benefits for their technologies, these are merely incremental improvements over traditional approaches. In sharp contrast, our proprietary technology delivers fully pure, homogeneous lineages—every single cell of the mice is derived exclusively from totipotent ES cells, with guaranteed 100% germline transmission efficiency. To experience these unparalleled benefits firsthand, enquire about your custom mouse model project with us or order embryos for in-house validation at your facility.
How much for a project assessment?
•Free initial design proposal with zero obligations.
•Request a free quote!
Who owns the mouse lP? Do l need a licence from Mingceler?
All model generation projects of Mingceler operate under a fee-for-service framework.
IP Ownership: All intellectual property rights related to custom mouse models, including derived organs, tissues, cells, and biological materials, are the sole and exclusive property of the Client.
Third-Party Transfer Permission: The Client may independently decide to retain, utilize, or commercialize their custom models project materials (e.g., targeting vectors, ES cells, mouse lines) without the need for prior consent from Mingceler.
Licensing Exemption: The Client has full autonomy over all uses of the custom models or their derivatives, including but not limited to commercialization, distribution to third parties, and publication involving model data. No written license from Mingceler is required for such uses.