hINHBE Mouse Model
| Strain Name | hINHBE Mouse Model |
|---|---|
| Strain Background | C57BL/6N |
Applications
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Liver–fat axis research: Study Activin E–ACVR1C signaling and PPAR gamma–mediated lipolysis control
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Obesity & T2D modeling: Model INHBE-driven visceral adiposity, insulin resistance, and metabolic syndrome
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INHBE-targeted drug evaluation: Test anti-INHBE ASOs, siRNAs, and Activin E–blocking antibodies
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NAFLD/NASH relevance: Correlate hepatic INHBE upregulation with steatosis and dyslipidemia
Strain Description
The hINHBE Mouse Model carries a targeted knock-in of the human INHBE gene at the endogenous mouse locus. It replaces the murine INHBE coding sequence while preserving native promoters and regulatory elements. Therefore, it ensures physiological expression of functional human INHBE protein in the same cell types where the endogenous gene is normally expressed, primarily hepatocytes. This human INHBE knock-in mouse produces human Activin E that signals through the liver–fat axis in a physiologically relevant manner.
This humanized INHBE model allows therapeutics to engage authentic human INHBE sequences. For example, you can test antisense oligonucleotides (ASOs) or GalNAc-siRNAs designed to silence human INHBE in hepatocytes. Similarly, it supports evaluation of neutralizing antibodies against Activin E. Consequently, the hINHBE Mouse Model provides a translational platform for INHBE-targeted drug efficacy, dose–response, and metabolic phenotype reversal that conventional models cannot replicate.
FAQ
Game-changing benefits？
While competitors highlight germline efficiency gains, shorter timelines and enhanced 3Rs animal welfare benefits for their technologies, these are merely incremental improvements over traditional approaches. In sharp contrast, our proprietary technology delivers fully pure, homogeneous lineages—every single cell of the mice is derived exclusively from totipotent ES cells, with guaranteed 100% germline transmission efficiency. To experience these unparalleled benefits firsthand, enquire about your custom mouse model project with us or order embryos for in-house validation at your facility.
How much for a project assessment?
•Free initial design proposal with zero obligations.
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Who owns the mouse lP? Do l need a licence from Mingceler?
All model generation projects of Mingceler operate under a fee-for-service framework.
IP Ownership: All intellectual property rights related to custom mouse models, including derived organs, tissues, cells, and biological materials, are the sole and exclusive property of the Client.
Third-Party Transfer Permission: The Client may independently decide to retain, utilize, or commercialize their custom models project materials (e.g., targeting vectors, ES cells, mouse lines) without the need for prior consent from Mingceler.
Licensing Exemption: The Client has full autonomy over all uses of the custom models or their derivatives, including but not limited to commercialization, distribution to third parties, and publication involving model data. No written license from Mingceler is required for such uses.