hFCRN Mouse Model
| Strain Name | hFCRN Mouse Model |
|---|---|
| Strain Background | C57BL/6N |
Applications
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IgG PK/PD & half-life: Assess IgG clearance and FcRn-driven half-life extension.
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Anti-FcRn drug testing: Evaluate blocking mAbs for IgG lowering in autoimmunity.
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Fc engineering: Compare wild-type vs high-affinity Fc variants for serum persistence.
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Mucosal transcytosis: Study IgG transport across placenta, gut, or respiratory epithelium.
Strain Description
The hFCRN Mouse Model carries a targeted knock-in of the human FCGRT gene at the endogenous mouse locus. It replaces the murine Fcgrn coding sequence while preserving native promoters and regulatory elements. Therefore, it ensures physiological, endothelial and epithelial expression of functional human FCRN.
In this hFCRN model, FCRN binds IgG and albumin in acidic endosomes and releases them at neutral pH. This salvage pathway prevents lysosomal degradation and prolongs IgG half-life in circulation. Furthermore, FCRN mediates IgG transcytosis across placental, intestinal, and bronchial barriers. Loss of FcRn function in the hFcRn mouse shortens IgG persistence, confirming its central role in antibody homeostasis and maternal–fetal transfer.
This humanized FCRN model allows therapeutics to engage authentic human FCRN.For example, you can test Fc-engineered antibodies with enhanced FCRN affinity to predict extended half-life. Similarly, it supports evaluation of anti-FCRN monoclonal antibodies (e.g., nipocalimab analogs) or FCRN-blocking fusion proteins. Consequently, the hFCRN Mouse Model provides a translational platform for IgG PK/PD and FcRn-targeted drug efficacy that conventional models cannot replicate.
FAQ
Game-changing benefits？
While competitors highlight germline efficiency gains, shorter timelines and enhanced 3Rs animal welfare benefits for their technologies, these are merely incremental improvements over traditional approaches. In sharp contrast, our proprietary technology delivers fully pure, homogeneous lineages—every single cell of the mice is derived exclusively from totipotent ES cells, with guaranteed 100% germline transmission efficiency. To experience these unparalleled benefits firsthand, enquire about your custom mouse model project with us or order embryos for in-house validation at your facility.
How much for a project assessment?
•Free initial design proposal with zero obligations.
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Who owns the mouse lP? Do l need a licence from Mingceler?
All model generation projects of Mingceler operate under a fee-for-service framework.
IP Ownership: All intellectual property rights related to custom mouse models, including derived organs, tissues, cells, and biological materials, are the sole and exclusive property of the Client.
Third-Party Transfer Permission: The Client may independently decide to retain, utilize, or commercialize their custom models project materials (e.g., targeting vectors, ES cells, mouse lines) without the need for prior consent from Mingceler.
Licensing Exemption: The Client has full autonomy over all uses of the custom models or their derivatives, including but not limited to commercialization, distribution to third parties, and publication involving model data. No written license from Mingceler is required for such uses.