hCYP3A4 Mouse Model
| Strain Name | hCYP3A4 Mouse Model |
|---|---|
| Strain Background | C57BL/6N |
Applications
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Preclinical ADME/PK studies: Assess human-relevant Phase I metabolism and clearance of CYP3A4 substrate drugs
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Drug–Drug Interaction (DDI) evaluation: Predict CYP3A4-based interaction risk (e.g., co-administration with known inducers/inhibitors)
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CYP3A4 enzyme induction & regulation research: Study PXR/CAR-dependent induction of human CYP3A4
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Metabolite identification: Generate human-like metabolite profiles for toxicology or bioanalysis
Strain Description
hCYP3A4 Mouse Model (hCYP3A4 knock-in) features targeted replacement of the murine CYP3A cluster with the human CYP3A4 gene under endogenous regulation, enabling physiological liver and intestinal expression of functional human CYP3A4.
This model overcomes species-specific metabolic gaps by recapitulating human-like oxidative metabolism, metabolite profiles, and enzyme induction. When paired with humanized nuclear receptors (e.g., PXR, CAR), it becomes a powerful translational platform for evaluating CYP3A4 substrates, inhibitors, and inducers in drug development.
FAQ
Game-changing benefits？
While competitors highlight germline efficiency gains, shorter timelines and enhanced 3Rs animal welfare benefits for their technologies, these are merely incremental improvements over traditional approaches. In sharp contrast, our proprietary technology delivers fully pure, homogeneous lineages—every single cell of the mice is derived exclusively from totipotent ES cells, with guaranteed 100% germline transmission efficiency. To experience these unparalleled benefits firsthand, enquire about your custom mouse model project with us or order embryos for in-house validation at your facility.
How much for a project assessment?
•Free initial design proposal with zero obligations.
•Request a free quote!
Who owns the mouse lP? Do l need a licence from Mingceler?
All model generation projects of Mingceler operate under a fee-for-service framework.
IP Ownership: All intellectual property rights related to custom mouse models, including derived organs, tissues, cells, and biological materials, are the sole and exclusive property of the Client.
Third-Party Transfer Permission: The Client may independently decide to retain, utilize, or commercialize their custom models project materials (e.g., targeting vectors, ES cells, mouse lines) without the need for prior consent from Mingceler.
Licensing Exemption: The Client has full autonomy over all uses of the custom models or their derivatives, including but not limited to commercialization, distribution to third parties, and publication involving model data. No written license from Mingceler is required for such uses.