C57BL/6J & 6N
I want to order some gene edited mice model. But I am curious about the different between C57BL/6J and 6N, are they the same or different? Actually, B6N are 99% identical to B6J, and they can be used for most…
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Category Resource&Article
The Living Test Tube: Mouse Models, ESC Technology, and the TurboMice™ Revolution
VeloGene Biotechnology The Living Test Tube skip render: ucaddon_list_marquee The Living Test Tube: Mouse Models, ESC Technology, and the TurboMice™ Revolution 1. Introduction: What is a Mouse Model? In modern biomedical research, understanding human disease requires more than test tubes…
Congenital Thrombotic Thrombocytopenic(cTTP)
What Is Congenital Thrombotic Thrombocytopenic Purpura? Congenital Thrombotic Thrombocytopenic Purpura (cTTP), also named congenital ADAMTS13 deficiency, is an extremely rare inherited hematologic disease. As one of the two major subtypes of thrombotic thrombocytopenic purpura (TTP), it differs from immune-mediated acquired…
VeloGene TurboMice™: Mono Chromosome Multipoint Gene Editing
Why VeloGene? TurboMice™ – Rapid Mouse Model Technology Mono Chromosome Multipoint Gene Editing VeloGene TurboMice™ Tetraploid Complementation Technology: Overcoming Multi-Loci Editing on the Same Chromosome, Delivering “Clone-Grade” Mice Directly at the F0 Generation In the construction of genetically engineered animal…
Addressing Postoperative Maternal Cannibalism in Laboratory Mice: A Technical Overview by VeloGene Biotechnology
Maternal cannibalism—the consumption or rejection of pups by the dam—represents a significant confounding variable in developmental and reproductive biomedical research. This phenomenon is not merely a welfare concern but a critical methodological issue that can compromise litter viability and data…
Isovaleric Acidemia
What Is Isovaleric Acidemia? Isovaleric Acidemia (IVA) is a rare autosomal recessive inborn organic acid metabolic disorder caused by pathogenic variants in the IVD gene encoding isovaleryl-CoA dehydrogenase. Gene defects block leucine catabolism, leading to massive systemic accumulation of toxic…
From a 35-Day Breakthrough to Next-Gen Model Generation: The Innovative Journey and Core Mission of VeloGene Biotechnology
Six years have quietly passed since our core scientific team completed a milestone technological leap in early 2020. Today, as global drug discovery pipelines accelerate at an unprecedented pace, the biotech industry increasingly demands smarter, faster, and more predictive preclinical…
Gangliosidosis：GM1/GM2-Tay-Sachs/Sandhoff
What Is Gangliosidosis? Gangliosidosis encompasses a group of autosomal recessive lysosomal storage diseases caused by defects in lysosomal hydrolases or accessory proteins, leading to pathological accumulation of gangliosides within the central nervous system (CNS). Based on the defective protein, the…
CDKL5 Deficiency Disorder (CDD)
What is CDKL5 Deficiency Disorder? CDKL5 Deficiency Disorder (CDD) is a rare X-linked genetic brain disorder caused by pathogenic variants in the cyclin-dependent kinase-like 5 (CDKL5) gene. Affected infants typically develop seizures within the first few months of life, accompanied…
Severe Congenital Neutropenia
What Is Severe Congenital Neutropenia? Severe Congenital Neutropenia (SCN) is a rare inherited bone marrow failure syndrome characterized by arrested myeloid differentiation, with an estimated prevalence of 3–8.5 cases per million people. Due to profound neutropenia, patients suffer recurrent infections…