In recent years, gene‑editing and AAV‑based gene therapies have frequently made headlines, hailed as beacons of hope for curing genetic diseases. What many overlook, however, is that before these cutting‑edge therapies advance to human trials, they must repeatedly pass a…
Biotinidase Deficiency (BTD) is an autosomal‑recessive inherited metabolic disorder. It is caused by pathogenic variants in the BTD gene that reduce or abolish biotinidase activity, impairing the recycling of free biotin. Officially listed in China’s First National Rare Disease Catalogue…
IgG4-related disease (IgG4-RD) is a chronic progressive fibrosing inflammatory disorder that received a unified international nomenclature in 2011. Capable of mimicking malignant tumors and involving nearly all visceral organs, it has become a core research focus in rheumatology and pathology.…
In July 2026, Nature Reviews Drug Discovery published the article Novel drug targets in 2025. According to its data, among the 94 innovative medicines approved by the world’s four major drug regulatory authorities in 2025, 11 targets represented globally first-in-class…
The global population living with type 2 diabetes mellitus (T2DM) has reached 590 million, and the figure is projected to rise to 700 million by 2045. Meanwhile, obesity remains a prevalent pandemic; over 30% of the population will be overweight…
I want to order some gene edited mice model. But I am curious about the different between C57BL/6J and 6N, are they the same or different? Actually, B6N are 99% identical to B6J, and they can be used for most…
VeloGene Biotechnology The Living Test Tube skip render: ucaddon_list_marquee The Living Test Tube: Mouse Models, ESC Technology, and the TurboMice™ Revolution 1. Introduction: What is a Mouse Model? In modern biomedical research, understanding human disease requires more than test tubes…
What Is Congenital Thrombotic Thrombocytopenic Purpura? Congenital Thrombotic Thrombocytopenic Purpura (cTTP), also named congenital ADAMTS13 deficiency, is an extremely rare inherited hematologic disease. As one of the two major subtypes of thrombotic thrombocytopenic purpura (TTP), it differs from immune-mediated acquired…
Why VeloGene? TurboMice™ – Rapid Mouse Model Technology Mono Chromosome Multipoint Gene Editing VeloGene TurboMice™ Tetraploid Complementation Technology: Overcoming Multi-Loci Editing on the Same Chromosome, Delivering “Clone-Grade” Mice Directly at the F0 Generation In the construction of genetically engineered animal…
Maternal cannibalism—the consumption or rejection of pups by the dam—represents a significant confounding variable in developmental and reproductive biomedical research. This phenomenon is not merely a welfare concern but a critical methodological issue that can compromise litter viability and data…
