hIL‑4RA Mouse Model
| Strain Name | hIL‑4RA Mouse Model |
|---|---|
| Strain Background | C57BL/6N |
Applications
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Anti‑IL‑4Rα drug evaluation: Test dupilumab‑like mAbs and next‑gen blockers
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Atopic dermatitis & asthma modeling: Study IL‑4/IL‑13–driven barrier defect, IgE, and AHR
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Th2 immunity research: Dissect JAK‑STAT6 signaling in T cells and epithelial cells
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Combo IO/anti‑allergy regimens: Validate IL‑4Rα blockade with other immunomodulators
Strain Description
The hIL‑4RA Mouse Model carries a targeted knock‑in of the human IL‑4RA gene at the endogenous mouse locus. It replaces the murine Il4racoding sequence while preserving native promoters and regulatory elements. Therefore, it ensures physiological expression of functional human IL‑4Rα protein in the same cell types and developmental stages as the endogenous mouse gene. As a result, this human IL‑4Rα knock‑in mouse mirrors human IL‑4/IL‑13 signaling more closely than wild‑type strains.
In this hIL‑4RA model, IL‑4 binds the type I receptor (IL‑4Rα–γc) and IL‑4 or IL‑13 binds the type II receptor (IL‑4Rα–IL‑13Rα1). Ligand engagement activates JAK1/TYK2 and STAT6, which induce Th2 differentiation, IgE class‑switching, and eosinophil recruitment. Furthermore, IL‑13–driven STAT6 signaling in epithelial cells suppresses filaggrin and ceramide synthesis, impairing barrier function in skin and lung.
This humanized IL‑4RA model allows therapeutics to engage authentic human IL‑4Rα epitopes. For example, you can test dupilumab‑like monoclonal antibodies that block IL‑4Rα and inhibit both IL‑4 and IL‑13 pathways. Similarly, it supports evaluation of IL‑4Rα‑targeted bispecifics or small molecules. Consequently, the hIL‑4RA Mouse Model provides a translational platform for Th2‑mediated disease research and anti‑IL‑4Rα drug efficacy that conventional models cannot replicate.
FAQ
Game-changing benefits？
While competitors highlight germline efficiency gains, shorter timelines and enhanced 3Rs animal welfare benefits for their technologies, these are merely incremental improvements over traditional approaches. In sharp contrast, our proprietary technology delivers fully pure, homogeneous lineages—every single cell of the mice is derived exclusively from totipotent ES cells, with guaranteed 100% germline transmission efficiency. To experience these unparalleled benefits firsthand, enquire about your custom mouse model project with us or order embryos for in-house validation at your facility.
How much for a project assessment?
•Free initial design proposal with zero obligations.
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Who owns the mouse lP? Do l need a licence from Mingceler?
All model generation projects of Mingceler operate under a fee-for-service framework.
IP Ownership: All intellectual property rights related to custom mouse models, including derived organs, tissues, cells, and biological materials, are the sole and exclusive property of the Client.
Third-Party Transfer Permission: The Client may independently decide to retain, utilize, or commercialize their custom models project materials (e.g., targeting vectors, ES cells, mouse lines) without the need for prior consent from Mingceler.
Licensing Exemption: The Client has full autonomy over all uses of the custom models or their derivatives, including but not limited to commercialization, distribution to third parties, and publication involving model data. No written license from Mingceler is required for such uses.