hCPEB Mouse Model
| Strain Name | hCPEB Mouse Model |
|---|---|
| Strain Background | C57BL/6N |
Applications
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Synaptic plasticity & LTP research: Study CPEB-mediated local mRNA translation and polyadenylation at dendritic spines
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Memory formation mechanisms: Model CPEB3 prion-like oligomerization and long-term memory consolidation (hippocampal dependency)
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Oncology relevance: Study CPEB1/CPEB4 dysregulation in glioma proliferation and tumor suppressor/tumor promoter roles
Strain Description
The hCPEB Mouse Model carries human CPEB1–4 genes. These replace the mouse CPEB orthologs at their native loci. Endogenous promoters and 3′UTRs remain intact. This ensures neuron-specific expression of functional human CPEB protein. The model includes prion-like domains found in CPEB2 and CPEB3.
CPEB proteins are master regulators of mRNA translation. They control cytoplasmic polyadenylation at synapses. This process is essential for long-term potentiation. It also supports memory consolidation and synaptic plasticity. The prion-like domains form self-perpetuating aggregates. These sustain local protein synthesis over time. This mechanism may explain long-term memory storage.
CPEB dysregulation links to many neurological disorders. These include autism spectrum disorder and fragile X syndrome. Huntington’s disease and gliomas are also implicated. The model includes a CPEB2-hnRNPA1PrDs humanized line. It recapitulates pathogenic cross-aggregation between RBPs. This is relevant to ALS and neurodegeneration research.
This model expresses human CPEB in a native context. It offers a powerful platform for studying translation control. It also supports therapeutic evaluation for neuropsychiatric diseases.
FAQ
Game-changing benefits？
While competitors highlight germline efficiency gains, shorter timelines and enhanced 3Rs animal welfare benefits for their technologies, these are merely incremental improvements over traditional approaches. In sharp contrast, our proprietary technology delivers fully pure, homogeneous lineages—every single cell of the mice is derived exclusively from totipotent ES cells, with guaranteed 100% germline transmission efficiency. To experience these unparalleled benefits firsthand, enquire about your custom mouse model project with us or order embryos for in-house validation at your facility.
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IP Ownership: All intellectual property rights related to custom mouse models, including derived organs, tissues, cells, and biological materials, are the sole and exclusive property of the Client.
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